Jumat, 26 Januari 2018

The Mesothelioma vaccine proved safe

According to a recent study conducted by a cancer research laboratory in the Netherlands, the newest new vaccine for mesothelioma can prevent and treat mesothelioma, a form of cancer that comes from exposure to asbestos. Researchers have tested vaccines in 10 patients who have been diagnosed with mesothelioma, with all of them showing elevated levels of antibodies to the disease and three of them suggest that the tumor has decreased in size.

What are the symptoms of mesothelioma cancer?

The study, published in the American Journal of Respiratory and Critical Care Medicine, explains how vaccines work by creating dendritic antigen cells in malignant mesothelioma tumors in the fluid layer in the patient's lungs. Dr Joachim Aerts, the study author and lung specialist at Erasmus Medical Center in Rotterdam, said the approach using the patient's immune system is useful for attacking the tumor and creating immunity to the disease, rather than using conventional radiation or with chemotherapy treatments.

How is histologic mesothelioma?

Dr Aerts says that this is one of the relatively new forms of treatment for a cancer called immunotherapy. The mesothelioma vaccine can be used and relatively safer, with few side effects when compared with current treatment methods. He expressed the hope that further studies could improve the survival rate of patients with mesothelioma disease. Currently, patients diagnosed with mesothelioma, the prognosis of their life is less than two years.

Patients who have been exposed to asbestos usually do not show symptoms of mesothelioma for several years, or even decades, after the initial exposure period. At that time, mesothelioma metastases will continue to run in the lungs and seep into other organs. The other side of the study is that vaccines can be a direct treatment for workers exposed to asbestos.

Although the side effects shown by patients in the study were not as severe as those experienced by chemotherapy or radiation treatments, one potential effect comes from changes in the patient's immune system during immunotherapy. The study noted that patients recovered quickly and showed no signs of autoimmune disease.

The difference between pleural mesothelioma and peritoneal mesothelioma
Dr Aerts notes that there are potential problems in immunosuppressive disorders. He said that the main problem for the treatment of mesothelioma is that the tumor creates an environment in the pleural mesothelium that can reduce the effects of the vaccine. He mentioned that the next step in vaccine development is how to give immunosuppressive around the cancer to improve the effectiveness of the treatment.

Dr. Aerts and his fellow researchers have done a number of tests on the effects on dendritic cells and how they can affect cancerous tumors in mice. Previous research has shown that vaccinations produce the antibodies necessary to destroy malignant cells and keep the surrounding healthy tissue to produce specific immunity.


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